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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
24.55
Human Site:
T158
Identified Species:
36
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
T158
R
R
Q
V
E
R
A
T
E
D
G
E
E
D
E
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
T149
R
R
Q
V
E
R
A
T
E
D
G
E
E
D
E
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
T158
R
R
Q
V
E
R
A
T
E
D
G
E
E
D
E
Dog
Lupus familis
XP_541736
1001
113024
T256
R
R
Q
V
E
R
A
T
E
D
G
E
E
D
E
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
T158
R
R
H
V
E
R
A
T
E
D
G
E
E
D
E
Rat
Rattus norvegicus
NP_001101343
905
102125
T159
R
R
H
I
E
R
A
T
E
D
G
E
E
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
A165
K
R
R
L
A
E
R
A
T
E
E
G
E
E
E
Chicken
Gallus gallus
NP_001006139
888
100332
D145
R
L
A
E
R
A
A
D
G
V
E
E
E
D
E
Frog
Xenopus laevis
P55861
886
100243
E143
R
M
A
E
R
A
A
E
G
A
P
E
E
D
E
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
A143
R
V
L
A
E
R
A
A
E
G
G
A
M
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
A143
R
R
A
G
E
K
A
A
V
G
E
V
E
D
T
Honey Bee
Apis mellifera
XP_395109
1005
114136
A262
R
R
M
A
E
K
A
A
I
G
E
I
E
D
T
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
P97
K
F
P
G
K
V
L
P
A
L
E
E
A
A
K
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
A143
R
R
M
A
E
R
A
A
E
G
I
E
D
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
R106
S
G
P
F
G
F
H
R
V
T
P
R
D
L
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
Y158
R
R
R
R
R
R
Q
Y
E
D
L
E
N
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
100
100
N.A.
93.3
86.6
N.A.
20
40
40
40
N.A.
40
40
6.6
60
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
53.3
40
40
46.6
N.A.
46.6
46.6
26.6
66.6
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
19
7
13
75
32
7
7
0
7
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
44
0
0
13
69
7
% D
% Glu:
0
0
0
13
63
7
0
7
57
7
32
69
69
13
63
% E
% Phe:
0
7
0
7
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
13
7
0
0
0
13
25
44
7
0
0
7
% G
% His:
0
0
13
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
7
0
7
7
0
0
0
% I
% Lys:
13
0
0
0
7
13
0
0
0
0
0
0
0
0
7
% K
% Leu:
0
7
7
7
0
0
7
0
0
7
7
0
0
7
0
% L
% Met:
0
7
13
0
0
0
0
0
0
0
0
0
7
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
13
0
0
0
0
7
0
0
13
0
0
0
0
% P
% Gln:
0
0
25
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
82
69
13
7
19
57
7
7
0
0
0
7
0
0
0
% R
% Ser:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% S
% Thr:
0
0
0
0
0
0
0
38
7
7
0
0
0
0
13
% T
% Val:
0
7
0
32
0
7
0
0
13
7
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _